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Tramadol has mu-opioid agonist activity. Tramadol HCl 37.5
mg/Acetaminophen 325 mg tablets, a tramadol-containing product, may be
sought by drug abusers and people with addiction disorders and may even
be susceptible to criminal diversion. The possibility of illegal or
illicit use should be thought about when prescribing or dispensing
Tramadol HCl 37.5 mg/Acetaminophen 325 mg tablets in situations in which
the physician or pharmacist is concerned about a increased
likelihood of misuse, abuse, or diversion. Misuse or abuse poses a
substantial risk to the abuser which could cause overdose and death (see
DRUG ABUSE AND DEPENDENCE and OVERDOSAGE).

The analgesic action of tramadol just isn’t fully understood,
but it’s believed to function with modulation of serotonin and
norepinephrine along with its relatively-weak -opioid receptor agonism.
The contribution of non-opioid activity is demonstrated through the fact
that the analgesic effect of tramadol isn’t fully antagonised by the
opioid receptor antagonist naloxone.

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