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Tramadol has mu-opioid agonist activity. Tramadol HCl 37.5 mg/Acetaminophen 325 mg tablets, a tramadol-containing product, may be sought by drug abusers and people with addiction disorders and may even be susceptible to criminal diversion. The possibility of illegal or illicit use should be thought about when prescribing or dispensing Tramadol HCl 37.5 mg/Acetaminophen 325 mg tablets in situations in which the physician or pharmacist is concerned about a increased likelihood of misuse, abuse, or diversion. Misuse or abuse poses a substantial risk to the abuser which could cause overdose and death (see DRUG ABUSE AND DEPENDENCE and OVERDOSAGE).

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The analgesic action of tramadol just isn’t fully understood, but it’s believed to function with modulation of serotonin and norepinephrine along with its relatively-weak -opioid receptor agonism. The contribution of non-opioid activity is demonstrated through the fact that the analgesic effect of tramadol isn’t fully antagonised by the opioid receptor antagonist naloxone.

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